No...I'm pretty sure it was because of ratings decline. It moved around so many time slots in its senior year that the ratings were so dismal, FOX canceled it. Here's the link to MITM's history on Wikipedia:
http://en.wikipedia.org/wiki/Malcolm_in_the_Middle.
It would be nice if we got the Futurama movies...I've found a few good laughs every now and then watching the show. I like the theme song
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